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IL36G (基因名), Interleukin-36 gamma (蛋白名), il36g_human.

产品名称:

IL36G Antibody

货号:

P2205Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

IL-1-related protein 2, Interleukin-1 epsilon, Interleukin-1 family member 9, Interleukin-1 homolog 1, IL-1RP2, IL-1 epsilon, IL-1F9, IL-1H1, UNQ2456/PRO5737, IL1E, IL1F9, IL1H1, IL1RP2

序列号:

Q9NZH8

反应性:

human

免疫原:

Recombinant human IL36G protein ( R2205h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human IL36G Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry of IL36G in human bladder tissue with IL36G antibody at 10 ug/mI.

通用注释

亚单元:

N/A

功能:

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.211238

SMR:

Q9NZH8

STRING:

9606.ENSP00000259205

KEGG:

hsa:56300

MIM: