首页 > 一抗 > KCNB2 Antibody

KCNB2 (基因名), Potassium voltage-gated channel subfamily B member 2 (蛋白名), kcnb2_human.

产品名称:

KCNB2 Antibody

货号:

P2325Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Voltage-gated potassium channel subunit Kv2.2

序列号:

Q92953

反应性:

human

免疫原:

corresponding to a sequence mapping at the 1-190aa of Q92953

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

关注

Human KCNB2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC analysis of in frozen sections of mouse brain extract using KCNB2 antibody.

通用注释

亚单元:

Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.

功能:

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.

亚细胞位置:

Cell membrane Multi-pass membrane protein Perikaryon Cell projection Dendrite Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.

数据库链接

UniGene:

Hs.661102

STRING:

9606.ENSP00000430846

KEGG:

hsa:9312

MIM:

607738

Pfam:

PF02214

Uniprot: