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MBNL1 (基因名), Muscleblind-like protein 1 (蛋白名), mbnl1_human.

产品名称:

MBNL1 Antibody

货号:

P15209Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Triplet-expansion RNA-binding protein, EXP, KIAA0428, MBNL

序列号:

Q9NR56

反应性:

human

免疫原:

Recombinant human MBNL1 protein ( R15209h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human MBNL1 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Rabbit Anti-MBNL1 Antibody; Paraffin Embedded Tissue: Human Heart; Cellular Data: Myocardial cells; Antibody Concentration: 5 ug/ml.

通用注释

亚单元:

Interacts with DDX1 and YBX1. Interacts with HNRNPH1; the interaction in RNA-independent.

功能:

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.

亚细胞位置:

Nucleus Cytoplasm Cytoplasmic granule Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress (PubMed:18335541). Localized in the cytoplasm of multinucleated myotubes (PubMed:18335541). Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy (PubMed:10970838, PubMed:11590133, PubMed:11929853).

数据库链接

UniGene:

Hs.201858

SMR:

Q9NR56

STRING:

9606.ENSP00000282486

KEGG:

hsa:4154

MIM:

160900

Pfam: