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MCL1 (基因名), Induced myeloid leukemia cell differentiation protein Mcl-1 (蛋白名), mcl1_human.

产品名称:

MCL1 Antibody

货号:

P2097Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl2-L-3, BCL2L3

序列号:

Q07820

反应性:

human,mouse,rat

免疫原:

Recombinant human MCL1 protein ( R2097h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human MCL1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical analysis of paraffin-embedded human breast cancer, using MCL1 antibody at 1:50 dilution.

通用注释

亚单元:

Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).

功能:

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

亚细胞位置:

Membrane Single-pass membrane protein Cytoplasm Mitochondrion Nucleus Nucleoplasm Cytoplasmic, associated with mitochondria.

数据库链接

UniGene:

Hs.632486

SMR:

Q07820

STRING:

9606.ENSP00000358022

KEGG:

hsa:4170

MIM: