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CD46 (基因名), Membrane cofactor protein (蛋白名), mcp_human.

产品名称:

CD46 Antibody

货号:

P1275Rb

商标:

EIAab^®

监管等级:

RUO

别名:

TLX, Trophoblast leukocyte common antigen, CD46, MCP, MIC10

序列号:

P15529

反应性:

human, mouse

免疫原:

Recombinant human CD46 protein ( R1275h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human CD46 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of paraffin embedded human hepatocarcinoma tissue using CD46 antibody dilution at: 1:50.

通用注释

亚单元:

(Microbial infection) Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

功能:

(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6 (PubMed:10972291, PubMed:12663806, PubMed:12724329, PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

亚细胞位置:

Cytoplasmic vesicle Secretory vesicle Acrosome inner membrane Single-pass type I membrane protein Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

数据库链接

UniGene:

Hs.510402

SMR:

P15529

STRING:

9606.ENSP00000313875

KEGG:

hsa:4179

MIM:

120920

Pfam: