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NR3C2 (基因名), Mineralocorticoid receptor (蛋白名), mcr_human.
产品名称:

NR3C2 Antibody

货号:

P0158Rb

商标:
EIAab®
监管等级:
别名:

Nuclear receptor subfamily 3 group C member 2, MR, MCR, MLR

序列号:
P08235
反应性:
human,mouse,rat
免疫原:
Recombinant human NR3C2 protein ( R0158h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Epigenetics
Human NR3C2 Polyclonal Antibody
规格 & 价格: cart
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Human NR3C2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical staining of human kidney using NR3C2 antibody shows distinct granular cytoplasmic positivity in cells in tubules.
通用注释


亚单元:
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.


功能:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.


亚细胞位置:
Cytoplasm Nucleus Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.


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