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ABCB1 (基因名), ATP-dependent translocase ABCB1 (蛋白名), mdr1_human.
产品名称:

ABCB1 Antibody

货号:

P8039Rb-h

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1, CD243, MDR1, PGY1

序列号:
P08183
反应性:
human
免疫原:
corresponding to a sequence mapping at the 996-1280aa of P08183
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Signal Transduction
  • Human ABCB1 Polyclonal Antibody
  • Human ABCB1 Polyclonal Antibody
  • Human ABCB1 Polyclonal Antibody
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Human ABCB1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS


R&D 技术数据
Human ABCB1 Polyclonal Antibody
HEK293T cells was subjected to SDS-PAGE followed by Western Blot with Multidrug resistance protein 1antibody at dilution of 1:300
Immunohistochemical staining of human liver using ABCB1 antibody shows cytoplasmic positivity in hepatocytes.
通用注释


亚单元:
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.


功能:
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).


亚细胞位置:
Cell membrane Multi-pass membrane protein Apical cell membrane


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