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MFN1 (基因名), Mitofusin-1 (蛋白名), mfn1_human.
产品名称:

MFN1 Antibody

货号:

P15253Rb

商标:
EIAab®
监管等级:
别名:

Fzo homolog, Transmembrane GTPase MFN1

序列号:
Q8IWA4
反应性:
human,mouse,rat
免疫原:
corresponding to a sequence mapping at the 2-77aa of Q8IWA4
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human MFN1 Polyclonal Antibody
规格 & 价格: cart
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Human MFN1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry: Mitofusin-1 Antibody - IHC staining of Mfn1 in mouse intestine.
通用注释


亚单元:
Homodimer, also in the absence of bound GTP (PubMed:27920125, PubMed:28114303). Forms higher oligomers in the presence of a transition state GTP analog (PubMed:28114303). Forms homomultimers and heteromultimers with MFN2 (By similarity). Oligomerization is essential for mitochondrion fusion (PubMed:27920125, PubMed:28114303). Component of a high molecular weight multiprotein complex (PubMed:12759376). Interacts with VAT1.


功能:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).


亚细胞位置:
Isoform 2 Cytoplasm


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