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MLKL (基因名), Mixed lineage kinase domain-like protein (蛋白名), mlkl_human.
产品名称:

MLKL Antibody

货号:

P1747Rb-h

商标:
EIAab®
监管等级:
别名:

hMLKL

序列号:
Q8NB16
反应性:
human
免疫原:
corresponding to a sequence mapping at the Recombinant protein of Q8NB16
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human MLKL Polyclonal Antibody
规格 & 价格: cart
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Human MLKL Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry of paraffin-embedded human liver cancer tissue using MLKL antibody.
通用注释


亚单元:
Homotrimer; forms homotrimers on necroptosis induction. Interacts with RIPK3; the interaction is direct. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3. Within this complex, may play a role in the proper targeting of RIPK1/RIPK3 to its downstream effector PGAM5.


功能:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.


亚细胞位置:
Cytoplasm Cell membrane Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.


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