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MTM1 (基因名), Myotubularin (蛋白名), mtm1_human.

产品名称:

MTM1 Antibody

货号:

P15150Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, CG2

序列号:

Q13496

反应性:

human,mouse,rat

免疫原:

Recombinant human MTM1 protein ( R15150h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human MTM1 Polyclonal Antibody

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产品说明书

数据表:

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R&D 技术数据

Immunohistochemistry of paraffin-embedded human pancreas using MTM1 antibody at 1:100 dilution.

通用注释

亚单元:

Interacts with MTMR12; the interaction modulates MTM1 intracellular localization. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.

功能:

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.

亚细胞位置:

Cytoplasm Cell membrane Peripheral membrane protein Cell projection Filopodium Cell projection Ruffle Late endosome Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation.

数据库链接

UniGene:

Hs.655056

SMR:

Q13496

STRING:

9606.ENSP00000359423

KEGG:

hsa:4534

MIM:

300415

Pfam: