首页 > 一抗 > MUC1 Antibody

MUC1 (基因名), Mucin-1 (蛋白名), muc1_human.

产品名称:

MUC1 Antibody

货号:

P0413Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Breast carcinoma-associated antigen DF3, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, PEMT, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, EMA, CA 15-3, KL-6, PUM, PEM, CD227, MUC-1, PUM

序列号:

P15941

反应性:

human

免疫原:

corresponding to a sequence mapping at the 31-200aa of P15941

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Signal Transduction

规格 & 价格:

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Human MUC1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
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R&D 技术数据

MUC1 antibody detects MUC1 protein at cytoplasm in human cervical cancer by immunohistochemical analysis.MUC1 antibody diluted at 1:100.

通用注释

亚单元:

The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding domain, and stimulates its transcription activity. Binds ADAM17. Isoform ZD forms disulfide-linked oligomers.

功能:

The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

亚细胞位置:

Mucin-1 subunit beta Cell membrane Cytoplasm Nucleus On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.

数据库链接

UniGene:

Hs.89603

SMR:

P15941

STRING:

9606.ENSP00000357380

KEGG:

hsa:4582

MIM:

113720

Pfam:

PF01390

Uniprot:

P15941

相关产品

Mouse Muc1 ELISA Kit

Bovine MUC1 ELISA Kit

Mouse Muc1 CLIA Kit

Bovine MUC1 CLIA Kit

Mouse Muc1 Protein

序列长度:

1255

序列:

仅供参考，详细请咨询（services@eiaab.com）

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TSANL

3D 模型:

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免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

多克隆抗体MUC1可以申请产品的免费试用装吗？

我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。

[2].

多克隆抗体MUC1说明书上的信息是及时更新的吗？

说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。

[3].

如何选择合适的一抗？

请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。

[4].

多克隆抗体MUC1在其他物种或应用中测试过吗？

所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。

[5].

如何保存多克隆抗体MUC1？

我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。

[6].

如何分装多克隆抗体MUC1？

请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。

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