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NDP (基因名), Norrin (蛋白名), ndp_human.

产品名称:

NDP Antibody

货号:

P14889Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein, EVR2

序列号:

Q00604

反应性:

human, mouse

免疫原:

corresponding to a sequence mapping at the 25-133aa of Q00604

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human NDP Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Formalin-fixed and paraffin-embedded human brain tissue reacted with NDP Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.?

通用注释

亚单元:

Homodimer; disulfide-linked. Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2).

功能:

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.522615

SMR:

Q00604

STRING:

9606.ENSP00000367301

KEGG:

hsa:4693

MIM: