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NFAT5 (基因名), Nuclear factor of activated T-cells 5 (蛋白名), nfat5_human.
产品名称:

NFAT5 Antibody

货号:

P3089Rb-h

商标:
EIAab®
监管等级:
别名:

T-cell transcription factor NFAT5, Tonicity-responsive enhancer-binding protein, TonE-binding protein, NF-AT5, KIAA0827, TONEBP

序列号:
O94916
反应性:
human
免疫原:
Recombinant human NFAT5 protein ( R3089h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cardiovascular
Human NFAT5 Polyclonal Antibody
规格 & 价格: cart
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Human NFAT5 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Immunohistochemical staining of human brain tissue using NFAT5 antibody.
通用注释


亚单元:
Homodimer when bound to DNA, completely encircles its DNA target. Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Does not bind with Fos and Jun transcription factors. Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation (PubMed:22266867).


功能:
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).


亚细胞位置:
Nucleus Cytoplasm Nuclear distribution increases under hypertonic conditions.


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