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NOTCH2 (基因名), Neurogenic locus notch homolog protein 2 (蛋白名), notc2_human.
产品名称:

NOTCH2 Antibody

货号:

P2420Rb-h

商标:
EIAab®
监管等级:
别名:

Notch 2

序列号:
Q04721
反应性:
human
免疫原:
Recombinant human NOTCH2 protein ( R2420h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human NOTCH2 Polyclonal Antibody
规格 & 价格: cart
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Human NOTCH2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: Notch-2 Antibody - Diluted 1:200 to detect Notch-2 in human kidney tissue.?
通用注释


亚单元:
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65 (By similarity). Interacts with HIF1AN. Interacts (via ANK repeats) with C8orf4, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737).


功能:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737).


亚细胞位置:
Notch 2 intracellular domain Nucleus Cytoplasm Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by C8orf4 (PubMed:25985737).


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