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NOTCH3 (基因名), Neurogenic locus notch homolog protein 3 (蛋白名), notc3_human.
产品名称:

NOTCH3 Antibody

货号:

P3908Rb

商标:
EIAab®
监管等级:
别名:

Notch 3

序列号:
Q9UM47
反应性:
human,mouse
免疫原:
Recombinant human NOTCH3 protein ( R3908h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human NOTCH3 Polyclonal Antibody
规格 & 价格: cart
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Human NOTCH3 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistrochemical analysis of formalin-fixed and paraffin-embedded human cancer tissue using NOTCH3 antibody.
通用注释


亚单元:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.


功能:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.


亚细胞位置:
Notch 3 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.


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