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NPHS1 (基因名), Nephrin (蛋白名), nphn_human.
产品名称:

NPHS1 Antibody

货号:

P0937Rb-h

商标:
EIAab®
监管等级:
别名:

Renal glomerulus-specific cell adhesion receptor, NPHN

序列号:
O60500
反应性:
human
免疫原:
Recombinant human NPHS1 protein ( R0937h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Signal Transduction
Human NPHS1 Polyclonal Antibody
规格 & 价格: cart
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Human NPHS1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: Nephrin Antibody - Mouse kidney tissue with Nephrin antibody at 2 ug/ml.
通用注释


亚单元:
Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Interacts with KIRREL3. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1 (By similarity). Interacts with NPHS2 (PubMed:11562357).


功能:
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.


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