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NR1H3 (基因名), Oxysterols receptor LXR-alpha (蛋白名), nr1h3_human.
产品名称:

NR1H3 Antibody

货号:

P2044Rb

商标:
EIAab®
监管等级:
别名:

Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, LXRA

序列号:
Q13133
反应性:
human,mouse,rat
免疫原:
Recombinant human NR1H3 protein ( R2044h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cardiovascular
Human NR1H3 Polyclonal Antibody
规格 & 价格: cart
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Human NR1H3 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
Heterodimer of LXRA and RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with SIRT1 and this interaction is inhibited by CCAR2.


功能:
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).


亚细胞位置:
Nucleus


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