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NR2C2 (基因名), Nuclear receptor subfamily 2 group C member 2 (蛋白名), nr2c2_human.

产品名称:

NR2C2 Antibody

货号:

P10644Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, TAK1, TR4

序列号:

P49116

反应性:

human,mouse

免疫原:

Recombinant human NR2C2 protein ( R10644h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human NR2C2 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemistry-Paraffin:NR2C2 Antibody - Staining of human endometrium shows nuclear positivity in glandular cells and cells in the endometrial stroma.

通用注释

亚单元:

Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain (By similarity). Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (PubMed:9556573). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity (PubMed:12486131). Interacts with NLRP10 (PubMed:22672233). Interacts (via ligand-binding region) with transcriptional corepressor JAZF1; the interaction promotes NR2C2-mediated transcriptional repression (PubMed:15302918).

功能:

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.555973

SMR:

P49116

STRING:

9606.ENSP00000320447

KEGG:

hsa:7182

MIM: