首页 > 一抗 > PARP2 Antibody

PARP2 (基因名), Poly [ADP-ribose] polymerase 2 (蛋白名), parp2_human.

产品名称:

PARP2 Antibody

货号:

P9945Rb

商标:

EIAab^®

监管等级:

RUO

别名:

ADP-ribosyltransferase diphtheria toxin-like 2, DNA ADP-ribosyltransferase PARP2, NAD(+) ADP-ribosyltransferase 2, Poly[ADP-ribose] synthase 2, Protein poly-ADP-ribosyltransferase PARP2, ARTD2, ADPRT-2, pADPRT-2, PARP-2, ADPRT2, ADPRTL2

序列号:

Q9UGN5

反应性:

human, mouse

免疫原:

Recombinant human PARP2 protein ( R9945h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

关注

Human PARP2 Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Immunohistochemical analysis of formalin-fixed paraffin embedded human brain tissue using PARP2 antibody.?

通用注释

亚单元:

Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3 (By similarity). Homo- and heterodimer with PARP1 (PubMed:20092359). Interacts weakly (via the PARP catalytic domain) with HPF1 (PubMed:27067600, PubMed:28190768).

功能:

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.409412

SMR:

Q9UGN5

STRING:

9606.ENSP00000250416

KEGG:

hsa:10038

MIM: