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PCSK1N (基因名), ProSAAS (蛋白名), pcsk1_human.

产品名称:

PCSK1N Antibody

货号:

P4804Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Proprotein convertase subtilisin/kexin type 1 inhibitor, pro-SAAS, Proprotein convertase 1 inhibitor

序列号:

Q9UHG2

反应性:

human

免疫原:

Recombinant human PCSK1N protein ( R4804h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human PCSK1N Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemistry-Paraffin: PCSK1N Antibody - Staining of human pancreas shows cytoplasmic positivity in endocrine cells.

通用注释

亚单元:

Interacts via the C-terminal inhibitory domain with PCSK1 66 kDa form.

功能:

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

亚细胞位置:

Secreted Golgi apparatus Trans-Golgi network A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).

数据库链接

UniGene:

Hs.522640

SMR:

Q9UHG2

STRING:

9606.ENSP00000218230

KEGG:

hsa:27344

MIM:

300399

Pfam: