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PDCD4 (基因名), Programmed cell death protein 4 (蛋白名), pdcd4_human.

产品名称:

PDCD4 Antibody

货号:

P2393Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, H731

序列号:

Q53EL6

反应性:

human,mouse,rat

免疫原:

Recombinant human PDCD4 protein ( R2393h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human PDCD4 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of human thyroid gland using PDCD4 antibody shows strong nuclear positivity in glandular cells.

通用注释

亚单元:

Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

功能:

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.

亚细胞位置:

Nucleus Cytoplasm Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133).

数据库链接

UniGene:

Hs.711490

SMR:

Q53EL6

STRING:

9606.ENSP00000280154

KEGG:

hsa:27250

MIM:

608610

Pfam: