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PDX1 (基因名), Pancreas/duodenum homeobox protein 1 (蛋白名), pdx1_human.

产品名称:

PDX1 Antibody

货号:

P9043Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, GSF, IPF-1, IUF-1, IDX-1, STF-1, PDX-1, IPF1, STF1

序列号:

P52945

反应性:

human,mouse

免疫原:

corresponding to a sequence mapping at the Recombinant protein of P52945

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

关注

Human PDX1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

PDX-1 was detected in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue using Anti-PDX-1 Polyclonal Antibody at 5 μg/mL.

通用注释

亚单元:

Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b complex.

功能:

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

亚细胞位置:

Nucleus Cytoplasm Cytosol

数据库链接

UniGene:

Hs.32938

SMR:

P52945

STRING:

9606.ENSP00000370421

KEGG:

hsa:3651

MIM: