首页 > 一抗 > PSENEN Antibody

PSENEN (基因名), Gamma-secretase subunit PEN-2 (蛋白名), pen2_human.

产品名称:

PSENEN Antibody

货号:

P3143Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Presenilin enhancer protein 2, MDS033, PEN2

序列号:

Q9NZ42

反应性:

human,rat

免疫原:

corresponding to a sequence mapping at the CNLERVSNEEKLNLCRKY of Q9NZ42

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

关注

Human PSENEN Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Immunohistochemistry of PSENEN in rat lung tissue with PSENEN antibody at 5 μg/ml.

通用注释

亚单元:

The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2.

功能:

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus Golgi stack membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

数据库链接

UniGene:

Hs.534465

SMR:

Q9NZ42

STRING:

9606.ENSP00000222266

KEGG:

hsa:55851

MIM:

607632

Pfam: