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PRF1 (基因名), Perforin-1 (蛋白名), perf_human.
产品名称:

PRF1 Antibody

货号:

P1317Rb-h

商标:
EIAab®
监管等级:
别名:

Cytolysin, Lymphocyte pore-forming protein, PFP, P1, PFP

序列号:
P14222
反应性:
human
免疫原:
corresponding to a sequence mapping at the 247-555aa of P14222
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Immunology
Human PRF1 Polyclonal Antibody
规格 & 价格: cart
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Human PRF1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human PRF1 Polyclonal Antibody
A549 lysate was subjected to SDS-PAGE followed by Western Blot with PRF1 antibody at dilution of 1:500 (Observed molecular weight is about 61kDa)
通用注释


亚单元:
Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation.


功能:
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.


亚细胞位置:
Cytoplasmic granule lumen Secreted Cell membrane Multi-pass membrane protein Endosome lumen Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.


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