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PLK2 (基因名), Serine/threonine-protein kinase PLK2 (蛋白名), plk2_human.

产品名称:

PLK2 Antibody

货号:

P12869Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Polo-like kinase 2, Serine/threonine-protein kinase SNK, Serum-inducible kinase, PLK-2, hSNK, SNK

序列号:

Q9NYY3

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the Recombinant protein of Q9NYY3

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Signal Transduction

规格 & 价格:

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Human PLK2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC-P: PLK2 antibody testing of human lung cancer tissue.

通用注释

亚单元:

Interacts with NSF; causing NSF dissociation from GRIA2. Interacts with CIB1.

功能:

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

亚细胞位置:

Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Cell projection Dendrite Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

数据库链接

UniGene:

Hs.398157

SMR:

Q9NYY3

STRING:

9606.ENSP00000274289

KEGG:

hsa:10769

MIM:

607023

Pfam: