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PLN (基因名), Cardiac phospholamban (蛋白名), ppla_human.

产品名称:

PLN Antibody

货号:

P1884Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

PLB, PLB

序列号:

P26678

反应性:

human

免疫原:

Recombinant human PLN Protein (R1884h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human PLN Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Mouse lung tissue lysate was subjected to SDS-PAGE followed by Western Blot with PLN antibody at dilution of 1:300 (Observed molecular weight is about 8kDa)

通用注释

亚单元:

Homopentamer (PubMed:16043693, PubMed:16897780). Interacts with HAX1 and ATP2A2 (PubMed:17241641).

功能:

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

亚细胞位置:

Endoplasmic reticulum membrane Single-pass membrane protein Sarcoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein Membrane Single-pass membrane protein Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).

数据库链接

UniGene:

Hs.170839

SMR:

P26678

STRING:

9606.ENSP00000350132

KEGG:

hsa:5350

MIM:

172405

Pfam: