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PRNP (基因名), Major prion protein (蛋白名), prio_human.

产品名称:

PRNP Antibody

货号:

P9345Rb

商标:

EIAab^®

监管等级:

RUO

别名:

ASCR, PrP27-30, PrP33-35C, CD230, PrP, ALTPRP, PRIP, PRP

序列号:

P04156

反应性:

human,mouse

免疫原:

Recombinant human PRNP Protein (R9345h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

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Human PRNP Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

IHC-P staining of mouse lung tissue using PRNP antibody,primary antibody dilution at 1:20.

通用注释

亚单元:

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization (PubMed:11524679, PubMed:11900542, PubMed:14623188, PubMed:17468747, PubMed:19204296, PubMed:19927125, PubMed:20375014, PubMed:20564047). Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with KIAA1191 (PubMed:21153684). Interacts with ADGRG6 (By similarity).

功能:

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

亚细胞位置:

Cell membrane Lipid-anchor GPI-anchor Golgi apparatus Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.

数据库链接

UniGene:

Hs.472010

SMR:

P04156

STRING:

9606.ENSP00000368752

KEGG:

hsa:5621

MIM:

123400

Pfam: