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PSIP1 (基因名), PC4 and SFRS1-interacting protein (蛋白名), psip1_human.

产品名称:

PSIP1 Antibody

货号:

P15031Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, DFS 70, DFS70, LEDGF, PSIP2

序列号:

O75475

反应性:

human

免疫原:

Recombinant human PSIP1 protein ( R15031h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Epigenetics

规格 & 价格:

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Human PSIP1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical analysis of monoclonal antibody to PSIP1 on formalin-fixed paraffin-embedded human testis.

通用注释

亚单元:

Monomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN.

功能:

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

亚细胞位置:

Nucleus Remains chromatin-associated throughout the cell cycle.

数据库链接

UniGene:

Hs.658434

SMR:

O75475

STRING:

9606.ENSP00000370109

KEGG:

hsa:11168

MIM: