首页 > 一抗 > RIPK1 Antibody

RIPK1 (基因名), Receptor-interacting serine/threonine-protein kinase 1 (蛋白名), ripk1_human.

产品名称:

RIPK1 Antibody

货号:

P15191Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Cell death protein RIP, Receptor-interacting protein 1, RIP-1, RIP, RIP1

序列号:

Q13546

反应性:

human

免疫原:

Recombinant human RIPK1 Protein (R15191h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

关注

Human RIPK1 Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

通用注释

亚单元:

(Microbial infection) Interacts with Murid herpesvirus 1 protein RIR1.

功能:

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512).

亚细胞位置:

Cytoplasm Cell membrane

数据库链接

UniGene:

Hs.519842

SMR:

Q13546

STRING:

9606.ENSP00000259808

KEGG:

hsa:8737

MIM: