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ROBO1 (基因名), Roundabout homolog 1 (蛋白名), robo1_human.
产品名称:

ROBO1 Antibody

货号:

P3270Rb-h

商标:
EIAab®
监管等级:
别名:

Deleted in U twenty twenty, H-Robo-1, DUTT1

序列号:
Q9Y6N7
反应性:
human
免疫原:
Recombinant human ROBO1 protein ( R3270h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
Human ROBO1 Polyclonal Antibody
规格 & 价格: cart
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Human ROBO1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemistry-Paraffin: ROBO1 Antibody - staining of paraffin embedded Human Liver.AP-staining.
通用注释


亚单元:
Homodimer. Dimerization is mediated by the extracellular domain and is independent of SLIT liganding (PubMed:24673457). Interacts with SLIT1 (By similarity). Interacts with SLIT2 (PubMed:10102268, PubMed:11404413, PubMed:17848514). Interacts with FLRT3 (PubMed:24560577). Interacts with MYO9B (via Rho-GAP domain) (PubMed:26529257).


功能:
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell projection Axon Detected at growth cones in thalamus neurons.


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