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RSPO1 (基因名), R-spondin-1 (蛋白名), rspo1_human.

产品名称:

RSPO1 Antibody

货号:

P3285Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Roof plate-specific spondin-1, hRspo1

序列号:

Q2MKA7

反应性:

human

免疫原:

corresponding to a sequence mapping at the 21-263aa of Q2MKA7

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human RSPO1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry-Paraffin: RSPO1 Antibody - Human spleen tissue with RSPO1 antibody at 2 ug/ml.

通用注释

亚单元:

Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with ZNRF3; promoting indirect interaction between ZNRF3 and LGR4 and membrane clearance of ZNRF3. Interacts with LGR4, LGR5 and LGR6. Identified in a complex composed of RNF43, LGR5 and RSPO1.

功能:

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

亚细胞位置:

Secreted Nucleus Seems to mainly localize to nucleoli.

数据库链接

UniGene:

Hs.135015

SMR:

Q2MKA7

STRING:

9606.ENSP00000348944

KEGG:

hsa:284654

MIM: