首页 > 一抗 > SESN1 Antibody

SESN1 (基因名), Sestrin-1 (蛋白名), sesn1_human.

产品名称:

SESN1 Antibody

货号:

P0440Rb

商标:

EIAab^®

监管等级:

RUO

别名:

p53-regulated protein PA26, PA26, SEST1

序列号:

Q9Y6P5

反应性:

human,mouse,rat

免疫原:

Recombinant human SESN1 protein ( R0440h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human SESN1 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical analysis of SESN1 staining in human brain formalin fixed paraffin embedded tissue section.

通用注释

亚单元:

Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (PubMed:25263562, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1 (PubMed:23274085). May interact with PRDX1 (PubMed:15105503).

功能:

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed.

亚细胞位置:

Nucleus Cytoplasm

数据库链接

UniGene:

Hs.591336

SMR:

Q9Y6P5

STRING:

9606.ENSP00000393762

KEGG:

hsa:27244

MIM: