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SIGLEC7 (基因名), Sialic acid-binding Ig-like lectin 7 (蛋白名), sigl7_human.
产品名称:

SIGLEC7 Antibody

货号:

P15137Rb-h

商标:
EIAab®
监管等级:
别名:

Adhesion inhibitory receptor molecule 1, CDw328, D-siglec, QA79 membrane protein, p75, AIRM-1, CD328, Siglec-7, AIRM1

序列号:
Q9Y286
反应性:
human
免疫原:
Recombinant human SIGLEC7 protein ( R15137h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Immunology
Human SIGLEC7 Polyclonal Antibody
规格 & 价格: cart
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Human SIGLEC7 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical staining of paraffin embedded human cancer tissue using SIGLEC7 antibody.
通用注释


亚单元:
Interacts with PTPN6/SHP-1 upon phosphorylation.


功能:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。
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