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SIRT6 (基因名), NAD-dependent deacetylase sirtuin-6 (蛋白名), sirt6_human.
产品名称:

SIRT6 Antibody

货号:

P2127Rb

商标:
EIAab®
监管等级:
别名:

SIR2-like protein 6, SIR2L6

序列号:
Q8N6T7
反应性:
human,mouse,rat
免疫原:
Recombinant human SIRT6 protein ( R2127h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Epigenetics
Human SIRT6 Polyclonal Antibody
规格 & 价格: cart
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Human SIRT6 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Immunohistochemical staining of paraffin embedded human breast carcinoma tissue using SIRT6 antibody.
通用注释


亚单元:
Interacts with RELA.


功能:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.


亚细胞位置:
Nucleus nucleoplasm Predominantly nuclear. Associated with telomeric heterochromatin regions.


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