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SMAD6 (基因名), Mothers against decapentaplegic homolog 6 (蛋白名), smad6_human.
产品名称:

SMAD6 Antibody

货号:

P2187Rb-h

商标:
EIAab®
监管等级:
别名:

SMAD family member 6, SMAD 6, MAD homolog 6, MADH6

序列号:
O43541
反应性:
human
免疫原:
Recombinant human SMAD6 protein ( R2187h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human SMAD6 Polyclonal Antibody
规格 & 价格: cart
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Human SMAD6 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of formalin-fixed and paraffin-embedded human lung cancer tissue using SMAD6 antibody.?
通用注释


亚单元:
Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with STAMBP and PRKX. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, including ACVR1B, BMPR1B and TGFBR1. In response to BMP2, but not to TGFB treatment, interacts with SMAD1, but not with SMAD2, nor with SMAD4; this interaction may inhibit SMAD1 binding to SMAD4. Interacts with HOXC8 and HOXC9. Interacts with PELI1; this interaction interferes with PELI1 complex formation with TRAF6, IRAK1, IRAK4 and MYD88 in response to IL1B and hence negatively regulates IL1R-TLR signaling.


功能:
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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