首页 > 一抗 > SNX9 Antibody

SNX9 (基因名), Sorting nexin-9 (蛋白名), snx9_human.

产品名称:

SNX9 Antibody

货号:

P11356Rb

商标:

EIAab^®

监管等级:

RUO

别名:

SH3 and PX domain-containing protein 1, SH3 and PX domain-containing protein 3A, Protein SDP1, SH3PX1, SH3PXD3A

序列号:

Q9Y5X1

反应性:

human,mouse,rat

免疫原:

Recombinant human SNX9 protein ( R11356h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human SNX9 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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通用注释

亚单元:

Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9. Interacts with ADAM9 and ADAM15 cytoplasmic tails.

功能:

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

亚细胞位置:

Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle Clathrin-coated vesicle Golgi apparatus Trans-Golgi network Cell projection Ruffle Cytoplasm Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.

数据库链接

UniGene:

Hs.191213

SMR:

Q9Y5X1

STRING:

9606.ENSP00000376024

KEGG:

hsa:51429

MIM:

605952

Pfam: