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SORBS1 (基因名), Sorbin and SH3 domain-containing protein 1 (蛋白名), srbs1_human.
产品名称:

SORBS1 Antibody

货号:

P3361Rb

商标:
EIAab®
监管等级:
别名:

Ponsin, SH3 domain protein 5, SH3P12, c-Cbl-associated protein, CAP, KIAA0894, KIAA1296, SH3D5

序列号:
Q9BX66
反应性:
human, mouse
免疫原:
corresponding to a sequence mapping at the Recombinant protein of Q9BX66
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human SORBS1 Polyclonal Antibody
规格 & 价格: cart
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Human SORBS1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical staining of SORBS1 in human heart muscle shows strong membranous and cytoplasmic positivity in myocytes.
通用注释


亚单元:
Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN.


功能:
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.


亚细胞位置:
Cell junction Adherens junction Cell membrane Cytoplasm Cytoskeleton Cell junction Focal adhesion Nucleus Nucleus matrix Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.


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