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SRGN (基因名), Serglycin (蛋白名), srgn_human.

产品名称:

SRGN Antibody

货号:

P1072Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Hematopoietic proteoglycan core protein, Platelet proteoglycan core protein, Secretory granule proteoglycan core protein, P.PG, PRG, PRG1

序列号:

P10124

反应性:

human

免疫原:

Recombinant human SRGN protein ( R1072h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human SRGN Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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通用注释

亚单元:

Binds to activated CD44 and to GZMB.

功能:

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

亚细胞位置:

Cytoplasmic granule Secreted Extracellular space Golgi apparatus Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).

数据库链接

UniGene:

Hs.1908

STRING:

9606.ENSP00000242465

KEGG:

hsa:5552

MIM:

177040

Pfam:

PF04360

Uniprot: