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STAT2 (基因名), Signal transducer and activator of transcription 2 (蛋白名), stat2_human.
产品名称:

STAT2 Antibody

货号:

P1796Rb

商标:
EIAab®
监管等级:
别名:

p113

序列号:
P52630
反应性:
human,mouse,rat
免疫原:
Recombinant human STAT2 protein ( R1796h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human STAT2 Polyclonal Antibody
规格 & 价格: cart
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Human STAT2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555). Interacts with Simian virus 5 protein V and rabies virus phosphoprotein. Interacts with human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth.


功能:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).


亚细胞位置:
Cytoplasm Nucleus Translocated into the nucleus upon activation by IFN-alpha/beta.


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