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TM4SF20 (基因名), Transmembrane 4 L6 family member 20 (蛋白名), t4s20_human.

产品名称:

TM4SF20 Antibody

货号:

P1147Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

UNQ518/PRO994

序列号:

Q53R12

反应性:

human

免疫原:

Recombinant human TM4SF20 protein ( R1147h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human TM4SF20 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry of paraffin embedded human colon cancer using TM4SF2O at dilution of 1:100.

通用注释

亚单元:

N/A

功能:

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).

亚细胞位置:

Membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20.

数据库链接

UniGene:

Hs.156652

SMR:

Q53R12

STRING:

9606.ENSP00000303028

KEGG:

hsa:79853

MIM:

615404

Pfam: