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TAOK2 (基因名), Serine/threonine-protein kinase TAO2 (蛋白名), taok2_human.

产品名称:

TAOK2 Antibody

货号:

P2239Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Kinase from chicken homolog C, Prostate-derived sterile 20-like kinase 1, Thousand and one amino acid protein kinase 2, hKFC-C, PSK-1, UNQ2971/PRO7431, KIAA0881, MAP3K17, PSK, PSK1

序列号:

Q9UL54

反应性:

human,mouse,rat

免疫原:

Recombinant human TAOK2 protein ( R2239h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

关注

Human TAOK2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemistry-Paraffin: TAOK2 Antibody - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

通用注释

亚单元:

Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2.

功能:

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

亚细胞位置:

Isoform 2 Cell projection Dendrite In dendrites, colocalizes with PCDH8.

数据库链接

UniGene:

Hs.291623

SMR:

Q9UL54

STRING:

9606.ENSP00000310094

KEGG:

hsa:9344

MIM: