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TBK1 (基因名), Serine/threonine-protein kinase TBK1 (蛋白名), tbk1_human.

产品名称:

TBK1 Antibody

货号:

P13052Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, NAK

序列号:

Q9UHD2

反应性:

human

免疫原:

Recombinant human TBK1 protein ( R13052h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human TBK1 Polyclonal Antibody

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产品说明书

数据表:

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R&D 技术数据

Immunohistochemical analysis of TBK1 in the cytosol and nucleus of paraffin-embedded mouse testis tissue using a TBK1 polyclonal antibody at a dilution of 1:200.

通用注释

亚单元:

(Microbial infection) Interacts with HCV NS3; this interaction leads to inhibition of cellular antiviral response by blocking necessary interactions between the TBK1 and its substrates IRF3 and IRF7.

功能:

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

亚细胞位置:

Cytoplasm Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.

数据库链接

UniGene:

Hs.505874

SMR:

Q9UHD2

STRING:

9606.ENSP00000329967

KEGG:

hsa:29110

MIM: