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PTGES3 (基因名), Prostaglandin E synthase 3 (蛋白名), tebp_human.

产品名称:

PTGES3 Antibody

货号:

P10319Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, cPGES, P23, TEBP

序列号:

Q15185

反应性:

human,mouse,rat

免疫原:

Recombinant human PTGES3 protein ( R10319h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human PTGES3 Polyclonal Antibody

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产品说明书

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R&D 技术数据

PTGES3 antibody detects PTGES3 protein at cytoplasm in mouse esophagus by immunohistochemical analysis. Sample: Paraffin-embedded mouse esophagus.

通用注释

亚单元:

Binds to the progesterone receptor (PubMed:8114727). Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex (PubMed:11274138). Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation (PubMed:24711448). Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2 (PubMed:27353360).

功能:

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.50425

SMR:

Q15185

STRING:

9606.ENSP00000262033

KEGG:

hsa:10728

MIM: