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TNFSF11 (基因名), Tumor necrosis factor ligand superfamily member 11 (蛋白名), tnf11_human.
产品名称:

TNFSF11 Antibody

货号:

P0855Rb-h

商标:
EIAab®
监管等级:
别名:

Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF, OPGL, RANKL, TRANCE, CD254, OPGL, RANKL, TRANCE

序列号:
O14788
反应性:
human
免疫原:
Recombinant human TNFSF11 Protein (R0855h)
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Immunology
  • Human TNFSF11 Polyclonal Antibody
  • Human TNFSF11 Polyclonal Antibody
  • Human TNFSF11 Polyclonal Antibody
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Human TNFSF11 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human TNFSF11 Polyclonal Antibody
Immunohistochemistry: TRANCE Antibody-Analysis of paraffin-embedded bladder cancer tissues using TNFSF11 with DAB staining.
通用注释


亚单元:
Homotrimer (By similarity). Interacts with TNFRSF11B (PubMed:22664871). Interacts with TNFRSF11A. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (By similarity).


功能:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).


亚细胞位置:
Tumor necrosis factor ligand superfamily member 11, soluble form Secreted


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