首页 > 一抗 > TNFRSF1A Antibody

TNFRSF1A (基因名), Tumor necrosis factor receptor superfamily member 1A (蛋白名), tnr1a_human.

产品名称:

TNFRSF1A Antibody

货号:

P0131Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, p55, p60, TNF-R1, TNF-RI, CD120a, TNFAR, TNFR1

序列号:

P19438

反应性:

human

免疫原:

corresponding to a sequence mapping at the 22-211aa of P19438

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

关注

Human TNFRSF1A Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献 ( 2 )
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

TNFRSF1A Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

通用注释

亚单元:

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway.

功能:

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

亚细胞位置:

Isoform 4 Secreted Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.

数据库链接

UniGene:

Hs.279594

SMR:

P19438

STRING:

9606.ENSP00000162749

KEGG:

hsa:7132

MIM: