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TRIM22 (基因名), E3 ubiquitin-protein ligase TRIM22 (蛋白名), tri22_human.

产品名称:

TRIM22 Antibody

货号:

P5012Rb

商标:

EIAab^®

监管等级:

RUO

别名:

50 kDa-stimulated trans-acting factor, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, Staf-50, Tripartite motif-containing protein 22, RNF94, STAF50

序列号:

Q8IYM9

反应性:

human, mouse

免疫原:

Recombinant human TRIM22 protein ( R5012h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human TRIM22 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical staining of human bone marrow using TRIM22 polyclonal antibody at 1:100.

通用注释

亚单元:

Homotrimer (PubMed:17156811). Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding (PubMed:18389079). Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination (PubMed:19218198).

功能:

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

亚细胞位置:

Cytoplasm Nucleus Nucleus speckle Nucleus Cajal body Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

数据库链接

UniGene:

Hs.501778

SMR:

Q8IYM9

STRING:

9606.ENSP00000369299

KEGG:

hsa:10346

MIM:

606559

Pfam: