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TRPV1 (基因名), Transient receptor potential cation channel subfamily V member 1 (蛋白名), trpv1_human.

产品名称:

TRPV1 Antibody

货号:

P12152Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Capsaicin receptor, Osm-9-like TRP channel 1, Vanilloid receptor 1, OTRPC1, TrpV1, VR1

序列号:

Q8NER1

反应性:

human,rat,mouse

免疫原:

corresponding to a sequence mapping at the Recombinant protein of Q8NER1

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Signal Transduction

规格 & 价格:

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Human TRPV1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of human breast cancer tissue using anti-TRPV1 polyclonal antibody at 1:100.

通用注释

亚单元:

Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with TMEM100.

功能:

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

亚细胞位置:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell projection Dendritic spine membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Mostly, but not exclusively expressed in postsynaptic dendritic spines.

数据库链接

UniGene:

Hs.579217

SMR:

Q8NER1

STRING:

9606.ENSP00000459962

KEGG:

hsa:7442

MIM:

602076

Pfam: