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TPSAB1 (基因名), Tryptase alpha/beta-1 (蛋白名), tryb1_human.

产品名称:

TPSAB1 Antibody

货号:

P1070Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Tryptase I, Tryptase alpha-1, Tryptase-1, TPS1, TPS2, TPSB1

序列号:

Q15661

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the 31-275aa of Q15661

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human TPSAB1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
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R&D 技术数据

Immunohistochemical of paraffin-embedded human appendix using TPSAB1 antibody at dilution of 1:50

通用注释

亚单元:

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

功能:

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).

亚细胞位置:

Secreted Released from the secretory granules upon mast cell activation.

数据库链接

UniGene:

Hs.405479

SMR:

Q15661

STRING:

9606.ENSP00000343577

KEGG:

hsa:7177

MIM: