首页 > 一抗 > UBE3A Antibody

UBE3A (基因名), Ubiquitin-protein ligase E3A (蛋白名), ube3a_human.

产品名称:

UBE3A Antibody

货号:

P9055Rb

商标:

EIAab^®

监管等级:

RUO

别名:

E6AP ubiquitin-protein ligase, HECT-type ubiquitin transferase E3A, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, E6AP, EPVE6AP, HPVE6A

序列号:

Q05086

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the 1-221aa of Q05086

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Neurosciences

规格 & 价格:

关注

Human UBE3A Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献 ( 1 )
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Formalin-fixed and paraffin-embedded human cancer tissue reacted with UBE3A polyclonal antibody which was peroxidaseconjugated to the secondary antibody followed by DAB staining.

通用注释

亚单元:

The active form is probably a homotrimer. Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with HCV core protein and targets it to degradation. Interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis. Interacts with BPY2. Interacts with HIF1AN, MAPK6 AND NEURL4; interaction with MAPK6 may be mediated by NEURL4. Interacts with the proteasomal subunit PSMD4. Interacts with ARNTL/BMAL1.

功能:

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).

亚细胞位置:

Nucleus Cytoplasm

数据库链接

UniGene:

Hs.598862

SMR:

Q05086

STRING:

9606.ENSP00000381045

KEGG:

hsa:7337

MIM: