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UCP1 (基因名), Mitochondrial brown fat uncoupling protein 1 (蛋白名), ucp1_human.

产品名称:

UCP1 Antibody

货号:

P2067Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Solute carrier family 25 member 7, Thermogenin, UCP 1, SLC25A7, UCP

序列号:

P25874

反应性:

human, mouse, rat

免疫原:

Recombinant human UCP1 protein ( R2067h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human UCP1 Polyclonal Antibody

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产品说明书

数据表:

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R&D 技术数据

Immunohistochemistry: UCP1 polyclonal antibody Staining of human breast cancer tissue at 1:200 dilution.

通用注释

亚单元:

Most probably functions as a monomer. Binds one purine nucleotide per monomer (By similarity). However, has also been suggested to function as a homodimer or a homotetramer (PubMed:24196960). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed:24196960).

功能:

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.

亚细胞位置:

Mitochondrion inner membrane Multi-pass membrane protein

数据库链接

UniGene:

Hs.249211

STRING:

9606.ENSP00000262999

KEGG:

hsa:7350

MIM:

113730

Pfam: